immunotherapy | Cytotoxic T cell therapy is a fundamental treatment of tumors.

페이지 정보

Author HK HIS Date19-09-16 18:20 View1,123 Comment0

본문

Cytotoxic T cell therapy, cytotoxic T lymphocytes have the effect of radically eliminating tumors.

Tumor cell immunotherapy

As the name suggests, tumor cell immunotherapy is a treatment that uses the body's powerful immune system to fight cancer. Our body's immune system is divided into three lines of defense to protect the health of the body. Skin, mucous membrane, respiratory, gastrointestinal, kidney and urinary tract: first line of defense. The second line of defense is phagocytosis, antimicrobial protein and inflammatory response. The third line of defense consists mainly of blood circulation and lymphatic circulation, and consists of immune organs (tonsils, lymph nodes, thymus, bone marrow, spleen, etc.) and immune cells (lymphocytes, macrophages, etc.). After the outbreak of cancer, the body mainly fights through the third line of the line of defense and all kinds of immune cells play a role. They need to be large and efficient army as well as excellent, wide range (immune cells), allowing soldiers to perform their duties. Most of the time in the army of immune cells from the blood is responsible for carrying oxygen, and red blood cells, platelets, are responsible for hematopoietic stem cells stemming from the bone marrow. If necessary, you will be overworked to deal with a large number of white blood cells with battle experience. Generally, only one part of the body patrol is sufficient. So what kind of leukocytes in your body fight cancer cells when they develop? NK cells (natural killer cells) of the innate immune system and T lymphocyte (cytotoxic T lymphocyte, CTL) of the acquired immune system are known to be the cells that attack the malignant tumor.

Natural Killer celll

Natural killer cells (NK cells) were discovered by the Heberman team in the 1970s. Plays an important role in early human defense systems and exhibits potent cytotoxic activity against tumor cells and virus infected cells without sensitizing the antigen. That is to say, NK cells spontaneously kill tumors, do not need to recognize tumor-specific antigens, and NK cells have an automatic quenching system.

The number of NK cells in childhood is relatively high, but the number of NK cells will decrease with age and the incidence of cancer will also increase. Currently, based on scientific theory and confirmed studies, a method has been established for large-scale cultivation and proliferation of highly active and highly pure human NK cells in vitro for the treatment of tumor patients.

Cytotoxic T cells (CTL cells)

Cytotoxic T-Cell (CTL) Cells are a major ruthless T-cell session with roles, and are key T cells that kill cancer cells. After these types of cells do not hesitate to CD3 + CD8 + molecular markers, they can directly mutate cells or cancer cells, cells attack "own" pathogens "identity inquiry" of MHC protein "perforin" and "gran The secretion of "Zyme" is passed through the cell (cell membrane) directly, allowing the cells to dissolve and die, and the dead phase is really horrible because it breaks down into many small pieces.

CTL-based multi-target antigen complex immunotherapy technology (MTCA-CTL) has emerged.

According to the Cancer Oncology Service Network, a global cancer cancer physician network, cell immunotherapy is constantly being upgraded due to continued improvements in cancer diagnosis and treatment techniques and a deeper understanding of the biological characteristics of cancer. Non-specific immunotherapy of cells expressing LAK cells The development of the fourth generation of DC-CIK-specific immunotherapies in the CIK generation, DC-CIK generation in the first generation representative DC-CIK specific immunotherapy is increasingly more accurate and targeted. Current domestic immunotherapy technology has been updated with the fifth generation MTCA-CTL immunotherapy. MHC-restricted CD8 + specific CTL cells can be expanded at a rate of 60-70% in cell culture products while ensuring expansion of non-MHC restricted NK-T cells. The combination of these makes the sterilization of cancer cells more efficient.

Five Advantages of MTCA-CTL Therapy!

1, safe and effective, no toxic side effects

Immune cell therapy is done by the patient's own immune cells, with no serious side effects except for minor side effects of fever, and the patient's physical burden is minimal.

2, more accurate target tumor killing effect

A completely new generation of MTCA-CTL rabbit immunotherapy, which aims to kill more precise tumor cells, is able to generate immune memory, adding a number of specific antigens, compared to killing the weak cell immunotherapy of tumor cells and non-specific antigens There is. Long-term and efficient induction of tumor activity;

3, the number of amplification is huge, improve tumoricidal effect

The next generation of MTCA-CTL rabbit disease treatment amplification efficiency is about 200 ~ 1000 times, the number of cell culture reaches 10 billion, and the tumor sterilization effect becomes high.

4, Improvement of immunity enhancement, sensitization and radiation treatment

MTCA-CTL rabbit disease treatment improves immunity after 48 hours of chemotherapy, reduces the side effects of chemotherapy, and provides the best treatment after more treatment.

5, individualized cell therapy program

In vivo, the immune cell level for each condition is immunologically in vivo before other cancer patients are treated with the next generation MTCA-CTL infected prior to receiving immunotherapy, resulting in a comprehensive understanding of the biological PD-1, NK, killer T cells The level of immune cells such as immune suppression and the body to determine the type and plan of cell therapy based on this to determine the response.

Treatment procedure

1, preprocessing inspection

Before treatment, the patient should take 2 ml of blood and perform an immune function test to evaluate the function of the immune function and target the necessary immune cells.

2, start treatment

Depending on the results of the test or the condition of the patient, the doctor agrees to initiate the treatment.

3, Blood collection

Send 50 ml of peripheral blood to the laboratory and send it to the culture.

4. Cell culture and processing

5, immune cells come back.

Proliferating activated immune cells are administered by intravenous reperfusion, and each culture is returned for 3 days once a day.

Treatment of MTCA-CTL immunotherapy

In advanced breast cancer, liver metastases and bone metastases, tumor markers returned to normal after treatment with MTCA-CTL immunotherapy. Imaging studies have shown that liver lesions have subsided considerably!

Patients with lung cancer with bone metastases

MTCA-CTL immunity, mediastinal lymph node metastasis, and systemic bone metastasis disappeared in the joints after brain metastasis, mediastinal metastasis and systemic metastasis.

How to choose immune cell therapy

In general, MTCA-CTL removes small residual tumor lesions after surgery, prevents metastasis and recurrence, quickly rescues surgery-induced immune damage, and improves the body's immune system. Combined radiation therapy can increase the sensitivity of radiation therapy, reduce the side effects of radiotherapy, and promote the recovery of the body's immune system. Combining chemotherapy increases the body's susceptibility to chemotherapy drugs, reduces the side effects of chemotherapy, and resists immunosuppressive effects of chemotherapy drugs. When treated with MTCA-CTL alone, many inflammatory cells are generated after activation, killing the tumor, inducing apoptosis of the tumor cells, and improving immunity. The goal of MTCA-CTL therapy is to fight against cancer cells by activating the immune system, but patients still have to choose carefully because of the high cost of the overall treatment! Combined with regular treatment, it can be considered as an adjunct to improving the body's immune system.

List
Reply

페이지 정보

관련링크

본문