What is tumor cell immunotherapy?

Cancer Immunocytochemistry treats foreign bodies such as cancer cells and viruses in the blood and immune cells fighting cancer in a laboratory to be administered to the patient. Today, standard therapies, including three major cancer therapies (surgery, chemotherapy, and radiation therapy), damage normal cells in addition to killing cancer cells. Cancer Immune Cell Therapy uses patient's own immune cells to attack cancer cells, does not attack normal cells, has no side effects, and can be used with three standard therapies. Recent studies have shown that immune cell therapy improves the efficacy of three standard therapies, improves patient survival and improves patient quality of life.

Japanese Cell Immunotherapy Technology Introduction

a · βT cells are a kind of cytotoxic T cells and mature cytotoxic T cells are stimulated by antigen to differentiate into cytotoxic T cells and memory cytotoxic T cells. The former can specifically kill target cells with antigens such as transplanted cells, tumor cells and cells infected with microorganisms. T cells are more deadly and can kill repeatedly target cells. a. After activation of βT cells, the attack against cancer cells is the strongest immune cell and is widely used in various early cancers.

γ · ΔT cell therapy 

γ · ΔT cells are another type of cytotoxic T cell and another force to attack cancer cells. Mature cytotoxic T cells are stimulated by the antigen to differentiate into cytotoxic T cells and memory cytotoxic T cells. The former can specifically kill target cells with antigens such as transplanted cells, tumor cells and cells infected with microorganisms. γ · ΔT cells are used in various cancers such as lung cancer and multiple myeloma. The University Hospital of Japan conducted clinical studies and the results were published in international journals.

NK cell therapy 

NK cells, known as natural killer cells, are cells that detect and attack cancer cells and virus-infected cells. It accounts for 10-20% of the lymphocytes of the blood and is a very strong killer immune cell.

Advantages of Custom Precision Complex Cell Therapy

1, safe and effective minimal side effects

Immune cell therapy is done by the patient's own immune cells, with no serious side effects except for minor side effects of fever, and the patient's physical burden is minimal. 

2, more accurate target tumor killing effect

By applying a new technique of antigen to kill tumor cells, more precise targeting compared to conventional cell immunotherapy, immunotherapy can kill tumor cells and produce immune memory induced by long-term and efficient. 

 3, the number of amplification is huge, improve tumoricidal effect 

Amplification efficiency of the new generation disease treatment is about 200 ~ 1000 times and the cell culture number reaches 10 billion, and the sterilization effect is increased. 

4, Improvement of immunity enhancement, sensitization and radiation treatment 

After 48 hours of chemotherapy, rabbit transmission can be used to improve immunotherapy and reduce the side effects of chemotherapy. After many courses of intensive care, you can get the best treatment effect.

5, individualized cell therapy program 

The immune cell level and condition of each tumor patient is different. Before receiving cell immunotherapy, a new generation of infectious disease therapies is tested against in vivo immune cells before treatment to fully understand PD-1, NK and killer T in vivo. The level of immune cells, such as cells, determines the type and plan of cell therapy based on this to understand immune suppression and the body's response. 

Clinical Effect of Personalized Precision Complex Cell Therapy

Since its establishment in 1999, Japan's first immune cell treatment facility has cured more than 20,000 patients, and its rich treatment experience and excellent treatment results can provide better treatment for patients.

 

Data on the treatment effects presented here include 5,460 patients, including the lung and the stomach, and completed one or more immunotherapy (6 times) from April 1999 to March 2009. , Colon, liver, pancreatic cancer, milk, uterine ovarian cancer patients.

 

As shown in the picture above, about half of the patients have contracted cancer or the progression of cancer is suppressed within a certain period (*).

※ disease control rate: 54.0%, complete remission 1.4%, partial remedy 11.9%, long term stability 12.1%, stability 28.6% 

Immune cell therapy group: disease control rate 53.4%, effective rate 21.7%, success rate 5.9% 

Immunotherapy combination group: disease control rate 57.4%, effective infection rate 27.4%, success rate 17.0% 

Therefore, immunotherapy with other treatments is more effective. 

Complete remission: All lesions disappeared from the image. 

Partial Remission: The lesion diameter is reduced by 30% or more and the lesion is reduced to 30% or less. 

Long-term stability: lasts more than 6 months 

Stable: Less than 6 months 

1. Pre-treatment screening

In order to choose the appropriate treatment, the patient must perform a variety of tests, including immune function tests and immunohistochemical staining. Patients should consult their physician before deciding which tests are performed.

2, start treatment

Depending on the results of the test or the condition of the patient, the doctor agrees to initiate the treatment.

3, Blood collection

First, take the first blood. The amount and method of blood collection depends on the type of treatment.

4. Cell culture and processing

5, Immune cell injection

Proliferation and activation Immune cells are administered to the cancer and lymph node sites.

Examples of Custom Precision Complex Cell Therapy

 

 

02 Japan fusion cell therapy

Fusion Cell Therapy is one of the world's leading cancer research centers, with the Dana-farber Cancer Institute at Harvard University and Tokyo Cihui Medical University being the most prospective cancer- Therapy. A new cancer treatment has been established so far using the patient's own cancer cells to attack the cancer cells.

Principles of fusion cell therapy

One of the causes of cancer formation is that the cancer cells are well hidden. Dendritic cells do not recognize cancer cells. Imagine the merging of cancer cells and dendritic cells. They form dendritic cells that have specific antigens on the surface of various cancer cells that have the ability to recognize tumor cells and return them to the conductor to teach somatic cells to recognize other cancer antigens is. Cancer cells, groups for finding antigens, groups for finding b antigen cancer cells, all together Together with enhanced T cells in the treatment of interleukin 12, can destroy them, can effectively increase the number of killer T cells, resulting in the best anti-cancer effect . It is currently being studied extensively internationally.

 

Simply put,

Patients use their own cancer cells to fuse with their own dendritic cells in vitro. 

New dendritic cells capable of expressing all cancer antigens were obtained and prepared as individualized fusion cell vaccines,

The fused cells are returned to the patient to recognize the cancer cells.

 

What does the fusion cell look like?

 

 

Four Advantages of Fusion Cell Therapy

Individualization: A fusion cell vaccine is a customized dendritic cell vaccine for each patient.

More precisely: a fusion cell vaccine can provide the immune system with all the marker information contained in the patient's own cancer cells and can produce a more accurate killer T cell unit that attacks cancer cells. 

More safety: Because the vaccine is based on the patient's own cells, there is little side effect and is the best treatment for the body. 

More efficient: new treatment of interleukin 12 can improve the effectiveness of the vaccine. 

Latest research on fusion cell therapy

1. Fifty-two clinical trials of fusion cell vaccine + IL12, including 15 patients with glioma glioma with no effect on radiotherapy and chemotherapy, in 15 patients with brain tumors (glioma) of the Chiu Hui Medical University. 64 years old, male: female = 10: 5)

The results are as follows: 

 

 

1 prevented 73% of the illness from getting worse. 

2. The result of image evaluation is "The clinical effectiveness rate reaches 40% and the effect is amazing. 

3. Cancer cells = effective against unknown cancer antigens; 

Prove that CTL can also cross the cerebrovascular barrier. 

5 Adverse reactions: Low fever occurs occasionally (confirmed to be within safety limits). 

One of the 40-year-old patients with polymorphic glioblastoma (the most malignant type) succeeded in the initial surgery, but unfortunately it recurred after 3 months and progressed rapidly through the fused cells. The vaccine was treated for 3 months and the lesion was reduced by 12.1 cm 3. 

2. According to David Dana Farber's study on the therapeutic effect of fusion cell vaccine against kidney cell carcinoma, this vaccine can induce various immune responses because it contains dendritic cells of patient and cancer antigen of patient. 

 

Professor David and his colleagues have shown that the combination of a combination vaccine and an anti-PD1 antibody can equally be applied to blood cancers such as leukemia and myeloma.

In this study, conjugated cell vaccination was given to patients with AML (more than half were over 60 years old) who had been treated with anticancer drugs. 

 

The results are as follows:

Fusion cell therapy can cause an immune response to leukemia, alleviate long-term symptoms, and maintain sustained relief. 

The worse survival rate of 71% for four years! 

The 5-year overall survival rate is over 75%!